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pentobarbital will lessen the extent or outcome of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the extent or outcome of mestranol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Contraindicated (1)pentobarbital will decrease the extent or influence of lo